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Knuckle Cream isn't just a product; it's a promise to help you get those even-toned, irresistibly soft hands you've always wanted. Applying knuckle cream to remove the discoloration. Knuckle cream is a handy product that can help even out the skin tone on your knuckles. Take a small amount of knuckle cream and gently massage it onto your knuckles. Be sure to follow the product's instructions for usage.